A hat-trick for Jacques Bouquot and return to form by Ryan Kirwan had the Nittany Lions flying high.
Shay Ciezki dominated the fourth quarter, and her 17 points stole the show and secured victory for Penn State.
The 5-3 victory marks Penn State's first victory in Yost Ice Arena since 2019 and first conference win this campaign.
The Nittany Lions haven't won in Ann Arbor since 2019.
The Nittany Lions lost a war of attrition with the Spartans able to outlast a fatigued defense for the win.
"You got to go into them all with the same mindset and just give everything."