Hardy's two punt returns for touchdowns set a school record and matched a Big Ten one.
The Nittany Lions were aided by three touchdown passes from Drew Allar, as well as two punt return touchdowns from Daequan Hardy.
Penn State men's basketball will play Illinois on February 21, while the women's team will play Ohio State on February 22.
Saturday's Homecoming game should be a rainy, windy affair.
The Nittany Lions outshot Clarkson 81-48.
UMass is 1-6 this season, with its lone win being a 41-30 victory over New Mexico State.