Penn State overcame a sluggish first half with 31 points and an interception in the second.
A 17-point third quarter powered Penn State to a 41-13 win over Northwestern.
The Nittany Lions will kick off against the Wildcats at noon on the Big Ten Network.
The Wildcats are 2-2 this season, including a 37-34 overtime win over Minnesota last week.
The Nittany Lions have thrived off short-gain plays and taking advantage of what opponents give them.
The Nittany Lions are 6-0 and are coming off a 63-0 victory over UMass Saturday. Penn State will take on Indiana following its highly-anticipated matchup with Ohio State.