Erica Dambach clinched her seventh consecutive NCAA Tournament Sweet Sixteen berth, which is tied for the longest active streak in Division I women's soccer.
The blue and white showed flashes of momentum but ultimately could never match the Wolverines' answers during the first game of the weekend series.
The Nittany Lions extended their three-game win streak as the season begins to wind down.
Qudas Wahab recorded his second double-double of the season, totaling 14 points and 12 rebounds.
Penn State will move on to the Sweet Sixteen after shutting out the Broncos.
The Nittany Lions and Wolverines have both had shaky starts to their seasons.